Born in Mutare, Mpambiro moved around Zimbabwe whilst growing up following her parents’ separation, often residing with her grandmother or aunts. Her music journey began after joining the choir, subsequently taking vocal and piano lessons as a child.
Whilst a teenager, one of Mpambiro’s friends helped get one of Zimbabwe’s biggest radio stations to play her music. This radio airplay was well-received and caught the attention of singer-songwriter Audius Mtawarira, who eventually became her mentor and helped her with improving her craft. With help from Zimbabwean musician Brian Soko in 2017, the duo were connected with South African musicians such Rouge and Priddy Ugly who featured her on their releases. During this time, Sha Sha also crossed paths with DJ Maphorisa through her cab driver. The two began working on ballads together and, with help from the latter, was able to meet future collaborators Mlindo the Vocalist and Don Laka
Sha Sha was signed to DJ Maphorisa’s label Blaqboy Music in 2018. After gaining prominence with her vocals on the songs “Akulaleki” by Samthing Soweto, “Nge Thanda Wena” by Mlindo The Vocalist and “We Mama” by Scorpion Kings, Sha Sha released her debut EP Blossom in 2019.